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Roflumilast acts differently to bronchodilators as it acts on the underlying condition, not primarily impacting on everyday symptoms.
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The FDA is reviewing additional data submitted by orlistat manufacturers on suspected cases of liver injury, and the issue has been discussed at the FDA
In four studies, two 12-month studies and two six-month studies, roflumilast showed clear therapeutic potential, decreasing exacerbations and improving lung function.
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Roflumilast is a new PDE4 inhibitor being developed specifically to target the chronic inflammation which is COPD-related.