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The results of the two six-month trials examining the additive effect of roflumilast on top of salmeterol or tiotropium support and extend the findings of the 12-month trials, by showing a clinically relevant lung function improvement in patients with im The most commonly reported adverse events included yellowing of the skin or whites of the eyes (jaundice), weakness, and stomach pain.
In four studies, two 12-month studies and two six-month studies, roflumilast showed clear therapeutic potential, decreasing exacerbations and improving lung function.
Details of the results of the four studies will be published in The Lancet on August 29.
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* Severe allergic reactions and anaphylaxis may require treatment with injectable epinephrine, asthma symptoms may require the use of inhaled bronchodilator solutions (those that do not contain sulfites). It would be prudent for people with severe sulfite
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