Worldwide, COPD kills four people every minute and the World Health Organization (WHO) predicts that it will be the third leading cause of death by 2030.
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May be only available option for uncommon conditions or for patient populations that have not been studied.
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The phase III placebo-controlled trials of roflumilast evaluated the treatment in two 12-month (Lancet 2009; 374: 685?) and two six-month studies (Lancet 2009; 374: 695?), involving 4,500 patients in ten countries.
Approximately 50% of the patients were concomitantly using long acting beta agonists.
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There was also a statistically significant difference with roflumilast in other prespecified endpoints, including median time to first exacerbation (moderate to severe in the salmeterol study, and mild, moderate and severe in the tiotropium study) and in
It will also be the first oral anti-inflammatory treatment for COPD patients.
The safety of consumers is of utmost importance to GSK. We continually monitor and evaluate reports of adverse effects associated with use of all of our products, including alli.
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