Chan, Lazarus, and Hakim are employees of Fresenius Medical Care North America.
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The lung function improvements on top of current bronchodilation clearly indicates that roflumilast improves lung function over and above what can be achieved with other COPD treatments alone.
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The phase III placebo-controlled trials of roflumilast evaluated the treatment in two 12-month (Lancet 2009; 374: 685?) and two six-month studies (Lancet 2009; 374: 695?), involving 4,500 patients in ten countries.
We clearly need new options for patients with COPD and the results of these studies, published in The Lancet, confirm that roflumilast is beneficial.
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The studies showed a reduction in moderate to severe exacerbations by 17 percent per patient per year (rate of 1.
There was also a statistically significant difference with roflumilast in other prespecified endpoints, including median time to first exacerbation (moderate to severe in the salmeterol study, and mild, moderate and severe in the tiotropium study) and in
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